As we worked to create a regional framework for Social Purpose Real Estate and non-profit colocation in St Louis we looked to the considerable experience of the 400+ non-profit centers in the U.S. and Canada that have preceded us. Our review of this experience suggests that we could gain six specific benefits (Table 1) from creating non-profit centers. 1. Co-locating non-profits can enhance access to services by integrating services and putting them together in one shared location. The measurable outcomes might be increased use of services, easier access for constituents, and the establishment of a continuum of care. 2. Co-locating non-profits can lower costs by sharing “back of house” supports such as accounting, human resources, and risk management. Further, reduced turnover and the benefit from being near other organizational directors and program administrators could contribute to the bottom line. The measurable outcomes could be increased operational strength and efficiency, lower costs, and better managed organizations. These benefits may be particularly valued by smaller non-profit organizations or by newer ones seeking to establish effective systems.